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Protective Potential
of Glimepiride and Nerium oleander Extract on
Lipid Profile, Body Growth Rate, and Renal Function in
Streptozotocin-Induced Diabetic Rats
Maged M. YASSIN1, Saleh N. MWAFY2
1Department of Biology, Faculty of Science, The Islamic University of
Gaza, P.O. Box 108, Gaza Strip, PALESTINE
2Department of Biology, Faculty of Science, Al-Azhar University of Gaza,
P.O. Box 1277, Gaza Strip, PALESTINE
Abstract:
This
study aimed to assess the protective potential of glimepiride and
Nerium oleander extract on lipid profile, body growth rate, and
renal function in streptozotocin-induced diabetic rats. The animals were
divided into control and experimental groups. The experimental group was
rendered diabetic by intraperitoneal injection of a single dose of 50
mg/kg body weight streptozotocin. Rats with glucose levels >200 mg/dl
were subdivided into 3 sub-groups. Rats in the first sub-group remained
without treatment and were considered diabetic. Those in the second and
third subgroups were orally administered 0.1 mg/kg body weight daily
glimepiride and 250 mg/kg body weight daily Nerium oleander
extract, respectively, for 4 weeks. In the streptozotocininduced
diabetic rats, serum triglycerides and cholesterol were significantly
increased whereas body growth rate was markedly decreased compared to
the controls. In contrast to uric acid and creatinine, urea
concentrations were markedly elevated. Treatment of diabetic rats with
glimepiride or plant extract improved all of these parameters,
indicating their antidiabetic efficacy.
Key
Words: Diabetes rats, lipids, growth rate, kidney, glimepiride,
Nerium oleander, protection
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